Anticancer natural product – Latest research on bergamot
Bergamot (Citrus bergamia Risso) as a source of nutraceuticals: Limonoids and flavonoids
•Limonoids were determined in bergamot fruits for the first time.
•Limonoid aglycones are the more abundant in seeds and peels.
•Significant amounts of limonoid were purified by means of preparative HPLC HPLC/PDA/MS from bergamot seeds and juice.
Limonoids are human health promoters, and have many pharmacological properties: anticancer, antioxidant, antibacterial and antifungal. To the best of the authors’ knowledge, there are no previous reports on the composition of limonoids in bergamot fruits, so the aim of this work was to characterize bergamot peel, pulp, seed and juice. Samples analysed showed the presence of both limonoids aglycones and glucosides. Limonoid aglycones are the most abundant in seeds and peels (70 and 80% of the total, respectively), while limonoid glucosides are the more abundant in juices and pulps (61 and 76% of the total, respectively). Moreover a method to isolate pure limonoids from bergamot seeds and juice by means of a 2D-HPLC/PDA/MS preparative system is proposed. Pure molecules isolated were used to build calibration curves to quantify limonoids in real samples. Isolation of nutraceuticals from seeds and juices can represent an advantageous way to re-evaluate these by-products.
Marina Russo – a, b,
Adriana Arigò – a,
Maria Luisa Calabrò – a,
Sara Farnetti – c,
Luigi Mondello – a, b, d,
Paola Dugo – a, b, d, ,
a – “Scienze del Farmaco e Prodotti per la Salute” Department, University of Messina, Viale Annunziata, 98168 Messina, Italy
b – Chromaleont s.r.l., c/o “Scienze del Farmaco e Prodotti per la Salute” Department, University of Messina, Viale Annunziata, 98168 Messina, Italy
c – Division of Cellular Transplantation of Surgery, Diabetes Research Institute, University of Miami, Miami, FL 33136, USA
d – University Campus Bio-Medico of Rome, Via Álvaro del Portillo, 21-00128 Rome, Italy
Received 22 June 2015, Revised 5 October 2015, Accepted 13 October 2015, Available online 10 November 2015
Anticancer natural product www.bergasterol.com
Bergamot and Cholesterol Research
By Leslie Seaton from Seattle, WA, USA (Bergamot) [CC BY 2.0 (http://creativecommons.org/licenses/by/2.0)], via Wikimedia Common
I located the following human studies of citrus bergamot and cholesterol:
A 2011 study titled Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies involved both people and lab rats. It involved 237 people who were followed for 30 days. The people were divided into 3 groups:
- Group A received 500 mg of bergamot per day before meals
- Group B received 1000 mg of bergamot per day before meals
- Group C received a placebo before meals
After the study researchers noted that bergamot caused a “strong reduction” in total cholesterol and LDL (bad cholesterol) and a significant increase in HDL (good cholesterol). A significant reduction in triglycerides was also seen. No significant changes were seen in those getting the placebo.
“ A strong reduction may not necessarily be a significant reduction. I thought some of the words used in this study were vague. Since this was an Italian study, this could be due to language differences between cultures. I recommend that doctors read the study for themselves. There was also a 4th group who had to stop taking their statin medications (cholesterol-lowering drugs) because of muscle pain and other side effects. They were given 1500 mg per day. This group showed saw a 25% reduction in total cholesterol and a 27.5% reduction in LDL (bad cholesterol) levels. No negative side effects were reported.“
In this study, those taking 1000 mg per day responded better than those getting 500 mg per day. This study also reported that bergamot improved vasodilation of the blood vessels. In other words, the blood vessels more easily opened up to allow for better blood flow. Because of this finding, I predict bergamot will be used in “male performance” supplements as well as “pre workout” supplements.”
In a 2013 study published in the International Journal of Cardiology that lasted 30 days, 1000 mg of bergamot, given to people with high cholesterol levels, was shown to significantly reduce total cholesterol, LDL cholesterol (bad cholesterol) and triglycerides while, at the same time, raising HDL (good cholesterol). Specifically, after 1 month of use, here is what the researchers found:
- The average total cholesterol dropped from 278 to 191.
- Levels of LDL decreased from an average of 191 to 113.
- Triglyceride levels dropped from 238 to 165.
- Levels of HDL increased from 38 to 45.
for you buy; Bergamot, lower cholesterol Agro Italia | Prodotti Agricoli Italiani
Calabrian bergamot natural remedy to lower the cholesterol level
Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia
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MAKE CHOLESTEROL LOWER WITH BERGAMOT AND BERGASTEROL
Bergamot is a citrus fruit/orange commonly grown in Calabria, Italy. It’s about the size of an orange, with a bitter taste.The bitterness of the fruit actually helps make Bergamot so remarkable and naturally lower cholesterol. Naringenin, a constituent in Bergamot that scientists have isolated gives citrus fruits their bitter taste and also provides a variety of health benefits.
BERGASTEROL 100% BERGAMOT JUICE FOR BALANCED CHOLESTEROL
Naringenin is known to increase antioxidant activity, which protects cells from oxidative stress. Antioxidants keep the body safe from free radicals and reduce the risk for diseases such as cancer and heart disease. While preventing harmful effects caused by free radicals is a major health benefit, scientists are more interested in the statin-like qualities of naringenin and other compounds in Bergamot. Researchers have been able to isolate 3-hydroxymethylyglutaryl flavonoid glycosides in citrus bergamot polyphenolic extract. These compounds exhibit an ability to inhibit cholesterol production in the liver, similarly to statin medicines.
BERGASTEROL 100% “JONICO” BERGAMOT JUICE A SAFE WAY TO GET YOUR CHOLESTEROL LOWER
Statin medicines can cause a variety of negative side effects: anything from headaches and nausea to drug interactions that may be cause further health risks. Statins slow the enzyme that causes cholesterol production, and they help clear LDL cholesterol from the bloodstream. Statins also help slow the formation of plaques, which cause blockage or arteries and reduce blood flow to extremities. When blood flow to the heart is blocked and reduced, the risk for heart disease and heart attack are greatly increased. Research shows that bergamot contains the same cholesterol reducing properties as these prescription medicines, making Bergasterol a natural option for cholesterol management. Bergamot has long been used for its anti-inflammatory effects, but new research supporting its ability to make total cholesterol lower, including lowering triglyceride levels and blood glucose, has medical specialists buzzing. More importantly, bergamot has also been shown to increase good cholesterol levels to support cholesterol management and promote cardiovascular health. Learn about clinical studies that have shown bergamot can lower cholesterol by up to 30%.
Some cardiologists are not prescribing statins routinely, but instead are offering some patients plant extracts instead to lower cholesterol, for example citrus bergamot. Intriguing is the use of citrus bergamot to normalize cholesterol with some patients, instead of routinely prescribing statins.
Citrus bergamot is becoming more popular as an alternative to statins on a global basis
Can citrus bergamot lower your cholesterol as opposed to taking prescription statin drugs? Recently have been appearing documents the health benefits/effects of citrus bergamot. Check out the site, “Health Benefits Of Bergamot.” A recently published research on Journal of Natural Products 2009 showed Citrus Bergamot has “statin like” principles, “carrying the 3-hydroxy-3-methylglutaric acid (HMG) moiety.” How healthy are the flavonoids?
Four flavonoids have been identified in citrus bergamot that are able to interfere with the natural synthesis of cholesterol in human body, by inhibiting the activity of the first enzyme in the cholesterol synthesis pathway: HMG-CoA reductase (3-hydroxy-3-methyl glutaril-coenzyme A reductase). These flavonoids is linked to 3-metil-3–hydroxy glutarile portion, which is exactly the substrate of HMG-CoA reductase.
This suggests that these compounds mimic endogenous HMG-CoA substrate and interfere with the synthesis of mevalonate, a critical compound at the top of the cholesterol synthesis pathway. By interfering with mevalonate synthesis, the polyphenolic flavanoids block the cholesterol production in the human body in a way similar to statins.
The presence of these flavones in the bergamot juice explains popular knowledge and recent clinical data on blood cholesterol-reducing potential of citrus bergamot. That’s some of the reasons why citrus bergamot has been offered to people who don’t want to take prescription statins as a possible alternative.
Flavones in citrus bergamot may lower cholesterol
Cholesterol-lowering properties of bergamot juice were discovered in an Italian study published in the November 2010 “Fitoterapia” journal. Bergamot reduced total cholesterol LDL — the bad cholesterol, triglycerides, and blood sugar and increased HDL — the good cholesterol, in patients with elevated cholesterol who consumed bergamot extract for 30 days, according to the study.
What researchers looked for was that bergamot inhibited the enzyme HMG-CoA reductase, which promotes cholesterol synthesis, and lowered blood pressure. Researchers found that HMG-CoA reductase is active when blood glucose is high. So, by lowering blood sugar levels, citrus bergamot also indirectly affects the activity of HMG-CoA reductase.
The Bergamot juice has also been found to contribute to a healthy heart
An Italian fruit Bergamot reduces “bad” cholesterol and improves “good” cholesterol, researchers say.
Scientists have claimed that it can even help patients taking heart pills to slash their dose, the Daily Express reported.
Research led by the University Magna Graecia in southern Italy showed that the could offer an effective alternative for people unable to tolerate statins, which have been hailed as a wonder drug for reducing cholesterol, the fat-like substance that furs up arteries, triggering heart attacks and strokes.
Trials in Italy on 237 patients showed that after 30 days using the fruit, total cholesterol levels were reduced by 38 percent.
Citrus bergamot has a distinctive aroma and is used in Earl Grey tea and perfumes.
The study has been published in the International Journal of Cardiology.
After a few years of recent studies on the bergamot juice as a remedy for cholesterol present our product “bergasterol” to the whole world.
Bergamot with the active highlighted by the university, is produced only in Calabria, southern Italy.
The origin and quality of Bergasterol bergamot juice give all the guarantees of effectiveness.
The Bergasterol is a unique and inimitable, you buy only from us.
Tip to lower cholesterol