medical research, hypercholesterolemic and bergamot

Bergamot juice, almost exclusively produced in Calabria (Italy), has always been used in folk medicine to reduce blood cholesterol and lipids.
Bergamot is an active ingredient based on balanced and highly standardized glycosilated polyphenols from bergamot, whose functional juice is reported to be traditionally effective against hypercholesterolemia, dyslipidemia and hyperglycemia.

studies and medical research:

Kurowska, E.M.; Manthey, J.A. Hypolipidemic effects and absorption of citrus

polymethoxylated flavones in hamsters with diet-induced hyper-cholesterolemia. J. Agric. Food

Chem. 2004, 52, 2879-2886.


Jung, U.J.; Kim, H.J.; Lee, J.S.; Lee, M.K.; Kim, H.O.; Park, E.J.; Kim, H.K.; Jeong, T.S.; Choi,

M.S. Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant

enzyme activities in hypercholesterolemic subjects. Clin. Nutr. 2003, 22, 561-568.


Kim, H.K.; Jeong, T.S.; Lee, M.K.; Park, Y.B.; Choi, M.S. Lipid-lowering efficacy of hesperetin

metabolites in high-cholesterol fed rats. Clin. Chim. Acta 2003, 327, 129-137.


Miceli, N.; Mondello, M.R.; Monforte, M.T.; Sdrafkakis, V.; Dugo, P.; Crupi, M.L.; Taviano,

M.F.; De Pasquale, R.; Trovato, A. Hypolipidemic effects of Citrus bergamia Risso et Poiteau

juice in rats fed a hypercholesterolemic diet. J. Agric. Food Chem. 2007, 55, 10671-10677.


Robards, K.; Li, X.; Antolovich, M.; Boyd, S. Characterization of Citrus by chromatographic

analysis of flavonoids. J. Sci. Food Agric. 1997, 75, 87-101.



Titolo: Evaluation of flavonoids and furanocoumarins from Citrus bergamia (Bergamot) juice and identification of new compounds
Autori: SIMONETTI, PAOLO (Ultimo autore)
Abstract: Bergamot juice (BJ) contains different classes of flavonoids (e.g. flavanones and flavones) that can exert beneficial effects on human health. The aim of this study was to evaluate the qualitative and quantitative composition of a BJ obtained from fruits harvested in Southern Italy (Calabria) at the end of their maturation period. The identity of several flavonoids and furanocoumarins was assessed by co-chromatography, UV spectra and molecular weight comparison. The unknown compounds were dissociated by induced collision (CID-MS) and their identity established through the characteristic ions product. By this approach a complete profile of about twenty compounds (furano-coumarins, flavonoids C- and O-glycosides) present in BJ was obtained. Furthermore, three acylated flavanones, present in amounts of 20.1±1.1, 89.3±2.2 and 190.1±3.1 mg/L, respectively, and which seem to correspond to di-oxalate derivatives of neoeriocitrin, naringin and neohesperidin, were identified for the first time in BJ. The other main flavanones were naringin, neohesperidin and neoeriocitrin, and their content was 167.5±1.8, 123.9±1.7 and 73.3±1.6 mg/L, respectively. Concerning flavones, the total amount in BJ was about 160 mg/L and the main ones were vicenin-2, stellarin-2, rhoifolin and neodiosmin. Bergapten and bergamottin were the primary furanocoumarins in BJ and their amounts were 9.0±0.4 and 18.2±0.5 mg/L, respectively.
Parole chiave: Flavonoids ; Furanocoumarins ; Bergamot juice ; LC ; Mass spectrometry
Settori scientifico disciplinari: BIO/09 – Fisiologia
Data di pubblicazione: 2008
Digital Object Identifier (DOI): 10.3390/molecules13092220
Citazione: Evaluation of flavonoids and furanocoumarins from Citrus bergamia (Bergamot) juice and identification of new compounds / C. Gardana, F. Nalin, P. Simonetti. – In: Molecules. – ISSN 1420-3049. – 13:9(2008), pp. 2220-2228.
Codice identificativo ISI: 000259735800013
Codice identificativo Scopus: 53249092189
Tipologia: Article (author)