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Bergamot and Cholesterol Research

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Bergamot and Cholesterol Research

By Leslie Seaton from Seattle, WA, USA (Bergamot) [CC BY 2.0 (http://creativecommons.org/licenses/by/2.0)], via Wikimedia Common

 

I located the following human studies of citrus bergamot and cholesterol:

A 2011 study titled  Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies involved both people and lab rats. It involved 237 people who were followed for 30 days. The people were divided into 3 groups:

  • Group A received 500 mg of bergamot per day before meals
  • Group B received 1000 mg of bergamot per day before meals
  • Group C received a placebo before meals

After the study researchers noted that bergamot caused a “strong reduction” in total cholesterol and LDL (bad cholesterol) and a significant increase in HDL (good cholesterol). A significant reduction in triglycerides was also seen. No significant changes were seen in those getting the placebo.

“ A strong reduction may not necessarily be a significant reduction. I thought some of the words used in this study were vague. Since this was an Italian study, this could be due to language differences between cultures. I recommend that doctors read the study for themselves. There was also a 4th group who had to stop taking their statin medications (cholesterol-lowering drugs) because of muscle pain and other side effects. They were given 1500 mg per day. This group showed saw a 25% reduction in total cholesterol and a 27.5% reduction in LDL (bad cholesterol) levels.  No negative side effects were reported.“

In this study, those taking 1000 mg per day responded better than those getting 500 mg per day. This study also reported that bergamot improved vasodilation of the blood vessels. In other words, the blood vessels more easily opened up to allow for better blood flow. Because of this finding, I predict bergamot will be used in “male performance” supplements as well as “pre workout” supplements.”

In a 2013 study published in the International Journal of Cardiology that lasted 30 days, 1000 mg of bergamot, given to people with high cholesterol levels, was shown to significantly reduce total cholesterol, LDL cholesterol (bad cholesterol) and triglycerides while, at the same time, raising HDL (good cholesterol). Specifically, after 1 month of use, here is what the researchers found:

  • The average total cholesterol dropped from 278 to 191.
  • Levels of LDL decreased from an average of 191 to 113.
  • Triglyceride levels dropped from 238 to 165.
  • Levels of HDL increased from 38 to 45.

for you buy; Bergamot, lower cholesterol Agro Italia | Prodotti Agricoli Italiani

Statin, flavonoids and bergamot juice

Some cardiologists are not prescribing statins routinely, but instead are offering some patients plant extracts instead to lower cholesterol, for example citrus bergamot. Intriguing is the use of citrus bergamot to normalize cholesterol with some patients, instead of routinely prescribing statins.
Citrus bergamot is becoming more popular as an alternative to statins on a global basis

Can citrus bergamot lower your cholesterol as opposed to taking prescription statin drugs? Recently have been appearing documents the health benefits/effects of citrus bergamot. Check out the site, “Health Benefits Of Bergamot.” A recently published research on Journal of Natural Products 2009 showed Citrus Bergamot has “statin like” principles, “carrying the 3-hydroxy-3-methylglutaric acid (HMG) moiety.” How healthy are the flavonoids?

Four flavonoids have been identified in citrus bergamot that are able to interfere with the natural synthesis of cholesterol in human body, by inhibiting the activity of the first enzyme in the cholesterol synthesis pathway: HMG-CoA reductase (3-hydroxy-3-methyl glutaril-coenzyme A reductase). These flavonoids is linked to 3-metil-3–hydroxy glutarile portion, which is exactly the substrate of HMG-CoA reductase.

This suggests that these compounds mimic endogenous HMG-CoA substrate and interfere with the synthesis of mevalonate, a critical compound at the top of the cholesterol synthesis pathway. By interfering with mevalonate synthesis, the polyphenolic flavanoids block the cholesterol production in the human body in a way similar to statins.

The presence of these flavones in the bergamot juice explains popular knowledge and recent clinical data on blood cholesterol-reducing potential of citrus bergamot. That’s some of the reasons why citrus bergamot has been offered to people who don’t want to take prescription statins as a possible alternative.

Flavones in citrus bergamot may lower cholesterol

Cholesterol-lowering properties of bergamot juice were discovered in an Italian study published in the November 2010 “Fitoterapia” journal. Bergamot reduced total cholesterol LDL — the bad cholesterol, triglycerides, and blood sugar and increased HDL — the good cholesterol, in patients with elevated cholesterol who consumed bergamot extract for 30 days, according to the study.

What researchers looked for was that bergamot inhibited the enzyme HMG-CoA reductase, which promotes cholesterol synthesis, and lowered blood pressure. Researchers found that HMG-CoA reductase is active when blood glucose is high. So, by lowering blood sugar levels, citrus bergamot also indirectly affects the activity of HMG-CoA reductase.

The Bergamot juice has also been found to contribute to a healthy heart

Tip to lower Cholesterol

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Bergamot with the active highlighted by the university, is produced only in Calabria, southern Italy.
The origin and quality of Bergasterol bergamot juice give all the guarantees of effectiveness.
The Bergasterol is a unique and inimitable, you buy only from us.

Tip to lower cholesterol